Improved ganoderic acids production in Ganoderma lucidum by wood decaying components

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Improved ganoderic acids production in Ganoderma lucidum by wood decaying components

Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). GAs are largely produced in the mushroom primordium and fruiting body but much less in mycelium stage. However, little is known on the underlying regulatory mechanism. As a saprophytic fungus, G. lucidum solely obtains nutrients...

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impact of rifampin induction on the fermentation production of ganoderic acids by medicinal mushroom ganoderma lucidum

backgrounds and objectives : ganoderic acids are the most valuable secondary metabolites in ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. however, application of ganoderic acids is limited due to low yield production. recently, it was shown that static liquid culture could be a proven technology for producing ganoderic acids in ganoder...

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A Novel Approach to Enhancing Ganoderic Acid Production by Ganoderma lucidum Using Apoptosis Induction

Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G. lucidum as a medicine. However, regulation of GA biosynthesis by various signaling remains poorly understood. This study investigated the role of apoptosis signaling on G...

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Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid

The effects of oxygen supply on the submerged fermentation of Ganoderma lucidum, a famous traditional Chinese medicinal mushroom, for simultaneous production of bioactive compounds—Ganoderma polysaccharide and ganoderic acid (GA) were studied. An initial volumetric oxygen transfer coefficient (KLa) value within the range of 16.4–96.0 h−1 had a significant effect on the cell growth, cellular mor...

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Separation of targeted ganoderic acids from Ganoderma lucidum by reversed phase liquid chromatography with ultraviolet and mass spectrometry detections

Separation of targeted ganoderic acids from Ganoderma lucidum by reversed phase liquid chromatography with ultraviolet and mass spectrometry detections Wen Tang a, Tingyue Gu b, Jian-Jiang Zhong a,c,∗ a State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China b Department of Chemical Engineering, Ohio University, A...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2017

ISSN: 2045-2322

DOI: 10.1038/srep46623